Prof Thomas Warner

Prof Thomas WarnerTel: 020 3448 3414
Fax: 020 3448 3954
Email: t.warner@ucl.ac.uk

Location:
National Hospital for Neurology and Neurosurgery

Specialities:
Movement disorders

Professional background

Professor Thomas Warner graduated from the University of Oxford in 1984 with a BA in physiological sciences.  He qualified as a Medical Practitioner in 1987 and his clinical education was at the University of Oxford School of Medicine.

Professor Warner completed his post-graduate medical education and obtained his MRCP in 1990 and FRCP in 2002. His higher neurological training was at the Royal Free Hospital, the National Hospital for Neurology and Neurosurgery, Queen Square, London and King’s College Hospital, London.  He was appointed Lecturer in Neurogenetics at the Institute of Neurology and obtained his PhD at the University of London. He was later appointed Senior Lecturer in Clinical Neurology and Consultant Neurologist at the Royal Free Hospital and Honorary Consultant Neurologist and Honorary Senior Lecturer at the National Hospital for Neurology and Neurosurgery (NHNN) and UCL Institute of Neurology. In 2002 he was promoted to Reader in Clinical Neuroscience at the Royal Free and University College London.

In 2011 he was promoted to Professor of Clinical Neuroscience at Institute of Neurology, UCL and he delivered his inaugural lecture in 2012. The same year he succeeded Professor Andrew Lees as Director of the Reta Lila Weston Institute at UCL Institute of Neurology.

Professor Warner is a member of the Association of British Neurologists (ABN) and the Movement Disorders Society and Medical  Advisor to the UK charity  “Dystonia Society”. He serves on the Scientific advisory committee and membership committee for the Movement Disorders Society and Teaching and Education committee for the ABN.  He is on the management committee for the EU COST funded project on dystonia syndromes. He has served on the editorial board for the  Movement Disorders Journal and as associate editor for the European Journal of Neurology. Professor Warner was awarded the Vera Down Award for Parkinson’s disease project alpha-synuclein in 1998. He was involved in developing the Multidisciplinary Huntington’s disease clinic at National Hospital for Neurology and Neurosurgery which received and NHS Good Practice Award in 2005.

Research interests

His major research interests are into the cellular pathogenesis of hereditary movement disorders including dystonia and parkinsonism as well as clinical studies in Huntington’s disease and experimental therapeutic trials in Parkinson’s disease and other movement disorders.

Publications

 

 

1.        Peall KJ, Smith DJ, Kurian MA, Wardle M, Waite AJ, Hedderly T, Lin JP, Smith M, Whone A, Pall H, White C, Lux A, Jardine P, Bajaj N, Lynch B, Kirov G, O'Riordan S, Samuel M, Lynch T, King MD, Chinnery PF, Warner TT, Blake DJ, Owen MJ, Morris HR. (2013) SGCE mutations cause psychiatric disorders. Clinical and genetic characterization. Brain 136:294-303.

2.        Casper C, Kalliolia E, Warner TT. (2013) Recent advances in the molecular pathogenesis of dystonia-plus syndromes and heredodegenerative dystonias. Current Neuropharmacology (in press)

3.       Gardiner A, Bhatia K, Stamelou M, Dale R,  Kurian M,  Schneider S,  Wali G, Counihan T, Spacey S, Valente E, Silveira-Moriyama L, Schapira A,  Teive H, Raskin S, Sander J, Lees A, Warner T, Kullmann D, Wood N, Hanna M, Houlden H. (2012) PRRT2 Gene Mutations: from Paroxysmal Dyskinesia to Episodic Ataxia and Hemiplegic Migraine. Neurology 79:2115-2121

4.        Clark CN, Weber YW, Lerche H, Warner TT.  (2012) Paroxysmal exercise induced dyskinesia of the hands. Mov Disord 27:1579-80.

5.        Casper, C.J., Warner, T.T., Taanman, J.-W. and Nathwani, A.C. (2012) Generation of iPS-derived dopaminergic neurons as an in-vitro model of rapid-onset dystonia parkinsonism.  Hum Gene Therapy, 22, A42-A43.

6.         Phukan J, Albanese A, Gasser T, Warner T. (2011) Primary dystonia and dystonia-plus syndromes: clinical characteristics, diagnosis and pathogenesis. Lancet Neurol 2011;10:1074-85.

7.        Granata A, Koo S-J, Haucke V, Schiavo G, Warner TT. (2011) COP9 controls the stability of selected synaptic proteins via a TorsinA–dependent process. EMBO Journal 30:183-191

8.        Cleeter M, Houlden H, Simons P, Al-Shawi R, StevaninG, Durr A, Hsuan J, Warner TT. (2011)Screening for mutations in phosphatidyl 4-kinase 2-alpha gene in autosomal recessive hereditary spastic paraplegia. Amyotroph Lateral Scler 12:148-9

9.        Granata A, Warner TT. (2010). The role of TorsinA in dystonia. Eur J Neurol 17, Suppl 1, 81-7.

10.     Warner, T. T., Granata, A., Schiavo, G. (2010). TorsinA and DYT1 dystonia: a synaptopathy? Biochem Soc Trans 38(2), 452-456

11.     Granata, A., Schiavo, G., Warner, T. T. (2009). TorsinA and dystonia: from nuclear envelope to synapse. Journal of Neurochemistry 109(6), 1596-1609

12.     Simons, J. P., Al-shawi, R., Minogue, S., Waugh, M. G., Wiedemann, C., Evangelou, S., Loesch, S., Sihra, T. S., King, R., Warner, T. T., Hsuan, J. J. (2009). Loss of phosphatidylinositol 4-kinase 2α activity causes late onset degeneration of spinal cord axons. Proceedings of the National Academy of Sciences of the United States of America 106(28), 11535-11539

13.     Smith, B. N., Bevan, S., Vance, C., Renwick, P., Wilkinson, P., Proukakis, C., Squitieri, F., Berardelli, A., Warner, T. T., Reid, E., Shaw, C. E. (2009). Four novel SPG3A/atlastin mutations identified in autosomal dominant hereditary spastic paraplegia kindreds with intra-familial variability in age of onset and complex phenotype. Clinical Genetics 75(5), 485-489

14.     Taanman, J. W., Daras, M., Albrecht, J., Davie, C. A., Mallam, E. A., Muddle, J. R., Weatherall, M., Warner, T. T., Schapira, A. H., Ginsberg, L. (2009). Characterization of a novel TYMP splice site mutation associated with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). Neuromuscul.Disord. 19(2), 151-154 

15.     Granata, A., Watson, R., Collinson, L. M., Schiavo, G., Warner, T. T. (2008). The dystonia-associated protein torsinA modulates synaptic vesicle recycling. Journal of Biological Chemistry 283(12), 7568-7579

16.     Salinas, S., Proukakis, C., Crosby, A., Warner, T. T. (2008). Hereditary spastic paraplegia: Clinical features and pathogenetic mechanisms. Lancet Neurology 7(12), 1127-1138

17.     Tsaousidou, M. K., Ouahchi, K., Warner, T. T., Yang, Y., Simpson, M. A., Laing, N. G., Wilkinson, P. A., Madrid, R. E., Patel, H., Hentati, F., Patton, M. A., Hentati, A., Lamont, P. J., Siddique, T., Crosby, A. H. (2008). Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration. American Journal of Human Genetics 82(2), 510-515

GMC/GDC number: 3202403