Prof Janice Holton

Dr Janice HoltonTel: 020 3448 4391
Fax: 020 3448 4486

National Hospital for Neurology and Neurosurgery

Neuropathology, Cellular Pathology - Neuropathology, Pathology

Professional background

Janice Holton is a Senior Lecturer and Honorary Consultant. She studied medicine at Leeds University Medical School and subsequently completed a PhD at the University of Southampton. Janice trained in general pathology in Leicester and in neuropathology in the Division of Neuropathology, UCL Institute of Neurology, Queen Square and is a Fellow of the Royal College of Pathologists. She was appointed Senior Lecturer in Neuropathology at the UCL Institute of Neurology and Honorary Consultant Neuropathologist at the National Hospital for Neurology and Neurosurgery in 1999 and has developed interests in neurodegenerative diseases and in muscle pathology, leading the diagnostic muscle pathology service. She has published a number of original papers and contributed to book chapters. She is an active member of the British Neuropathological Society in which she has previously held the office of Honorary Treasurer and is currently Programme Secretary. She is a member of the founding Council of the British Myology Society.

Research interests

  • Muscle pathology
  • Neurodegenerative disease


1. International consensus on a proposed score system for muscle biopsy evaluation in patients with juvenile dermatomyositis: A tool for potential use in clinical trials. Wedderburn LR, Varsani H, Li CK, Newton KR, Amato AA, Banwell B, Bove KE, Corse AM, Emslie-Smith A, Harding B, Hoogendijk J, Lundberg IE, Marie S, Minetti C, Nennesmo I, Rushing EJ, Sewry C, Charman SC, Pilkington CA, Holton JL; UK Juvenile Dermatomyositis Research Group.  (2007) Arthritis Rheum.  57(7):1192-1201

2. MHC Class I overexpression on muscles in early juvenile dermatomyositis. Li CK, Varsani H, Holton JL, Gao B, Woo P, Wedderburn LR. (2004) J Rheumatol, 31: 605-9

3. Quantification of normal range of inflammatory changes in morphologically normal pediatric muscle. Varsani H, Newton KR, Li CK, Harding B, Holton JL, Wedderburn LR. (2008) Muscle Nerve 37(2): 259-261

4. Conspicuous involvement of desmin tail mutations in diverse cardiac and skeletal myopathies. Bar H, Goudeau B, Walde S, Casteras-Simon M, Mucke N, Shatunov A, Goldberg YP, Clarke C, Holton JL, Eymard B, Katus HA, Fardeau M, Goldfarb L, Vicart P, Herrmann H. (2007) Hum Mutat. 28(4):374-86

5. Lewy bodies in grafted neurons in patients with Parkinson’s disease suggest host-to-graft disease propagation. Li Y, Englund E*, Holton JL*, Soulet D, Hagell P, Lees AJ, Lashley T, Quinn NP, Rehncrona S, Björklund A, Widner H, Revesz T, Lindvall O, Brundin P. (2008) Nat Med 14: 501-503  (*Denotes equal contribution)

6. Neuropathology of primary adult onset dystonia. Holton JL, Schneider SA, Ganesharajah T, Gandhi S, Strand C, Shashidharan P, Barreto J, Wood NW, Lees AJ, Bhatia KP, Revesz T (2008) Neurology 70: 695-699

7. Familial Danish Dementia: A Novel Form of Cerebral Amyloidosis Associated with Deposition of Both Amyloid-Dan and Amyloid-Beta. Holton JL, Lashley T, Bojsen Møller M, Vidal R, Guerin C, Gibb G, Rostagno A, Braendgaard H, Anderton BH, Plant G, Ghiso J, Frangione B, Revesz T. (2002) J Neuropathol Exp Neurol, 61: 254-267

8. Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease. Lashley T, Revesz T, Plant G, Bandopadhyay R, Lees AJ, Frangione B, Wood NW, de Silva R, Ghiso J, Rostagno A, Holton JL. (2008) Neuropathol Appl Neurobiol. 34(5):492-505

9. The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations. Ozawa T, Paviour D, Quinn NP, Josephs KA, Sangha H, Kilford L, Healy DG, Wood NW, Lees AJ, Holton JL, Revesz T. (2004) Brain, 127:2657-2671

10. Pathological tau burden and distribution distinguishes progressive supranuclearpalsy-parkinsonism from Richardson's syndrome. Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. (2007) Brain. 130(Pt 6):1566-76.

GMC/GDC number: 2827382