Dupuytrens contracture trial 

11/03/2019 00:00 

University College Hospital is taking part in a trial which is looking to assess whether a collagenase injection or surgery is a more effective way of treating Dupuytren’s contracture of the hand.

Dupuytren’s contracture is a common condition caused by fibrous tissue which forces the finger to bend down into the palm meaning patients cannot straighten their finger. The common treatment is surgery to remove the tissue and straighten the bent finger.

A new treatment is a collagenase injection, which weakens the cord at the point of injection, allowing a manipulation to be performed to break or snap the cord thus straightening the finger. This is given in clinic, and is followed up in clinic a few days later where the finger is moved to help to straighten it.

Both treatments are offered on the NHS in England and are used in the USA and Europe, but it is not known if the injection is as good as surgery at correcting the bent finger, if the correction continues in the long term and if the complication rates are similar.

The aim of this study is to find out whether collagenase injections are as good and as safe as surgery for treating this condition and to find out the cost of both treatments to see which is the best value for money. Participants are also asked what they think about the different treatments, to see if they prefer one treatment more than the other.

The trial, called Dupuytren’s Interventions Surgery vs Collagenase Trial, or DISC, is a multicentre, pragmatic randomised controlled trial funded by the National Institute for Health Research’s Health Technology Assessment Programme and sponsored by University Hospitals of Leicester NHS Trust.

More detailed information and eligibility criteria can be found here.

If you wish to refer a patient to UCLH for inclusion in the trial, please contact Judith Brahame, PA to Ms Anthea Davy, on j.brahame@nhs.net or 020 3447 5046.

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